Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab82126 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris Cl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0

General Info

  • Alternative names
    • CLL associated antigen KW 7
    • CLL-associated antigen KW-7
    • Dense fine speckles 70 kDa protein
    • DFS 70
    • DFS70
    • LEDGF
    • Lens epithelium derived growth factor
    • Lens epithelium-derived growth factor
    • MGC74712
    • p52
    • p75
    • PAIP
    • PC4 and SFRS1 interacting protein
    • PC4 and SFRS1 interacting protein 1
    • PC4 and SFRS1 interacting protein 2
    • PC4 and SFRS1-interacting protein
    • PSIP 1
    • PSIP 2
    • Psip1
    • PSIP1_HUMAN
    • PSIP2
    • Transcriptional coactivator p75/p52
    see all
  • FunctionTranscriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.
  • Tissue specificityWidely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions.
  • Involvement in diseaseNote=A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4.
  • Sequence similaritiesBelongs to the HDGF family.
    Contains 1 PWWP domain.
  • DomainResidues 340-417 are necessary and sufficient for the interaction with HIV-1 IN (IBD domain).
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationNucleus. Remains chromatin-associated throughout the cell cycle.
  • Information by UniProt

References for Recombinant Human PSIP1 protein (ab82126)

ab82126 has not yet been referenced specifically in any publications.

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