The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). In case of HIV-1 infection, suppresses Tat-mediated transactivation.
Belongs to the AAA ATPase family.
Sumoylated by UBE2I in response to MEKK1-mediated stimuli.