Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity.
Highly expressed in embryonic stem cells (ESCs). Expression decreases as ESCs differentiate.
Belongs to the proteasome subunit S9 family. Contains 1 PCI domain.