Tumor necrosis factor superfamily member 5-induced protein 1
FunctionChaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
Tissue specificityWidely expressed with highest levels in lung, brain and colon. Moderately expressed in muscle, stomach, spleen and heart. Weakly expressed in small intestine, pancreas and liver. Highly expressed in hepatocellular carcinomas with low levels in surrounding liver tissue.
Sequence similaritiesBelongs to the PSMG2 family.
Post-translational modificationsDegraded by the proteasome upon completion of 20S proteasome maturation.