Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • Amino acids2 to 173

Specifications

Our Abpromise guarantee covers the use of ab42570 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity0.9 U/ug. One unit will hydrolyze 1 pmol 6, 8-difluoro-4-methyl umbelliferyl phosphate (DiFMUP) per minute at pH 6.3 and 30?C. Assay buffer: 50 mM Bis-Tris, pH 6.3, 2 mM EDTA, 2 mM DTT, 100 mM DiFMUP.
  • Applications

    Inhibition Assay

  • Purity> 95 % SDS-PAGE.

  • FormLiquid
  • Additional notes 0.9 U/ug. One unit will hydrolyze 1 pmol 6, 8-difluoro-4-methyl umbelliferyl phosphate (DiFMUP) per minute at pH 6.3 and 30?C. Assay buffer: 50 mM Bis-Tris, pH 6.3, 2 mM EDTA, 2 mM DTT, 100 mM DiFMUP.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 50% Glycerol, Tween 20, 75mM Sodium chloride, 25mM Tris HCl, 2mM EDTA, 10mM Glutathione, 1mM DTT, pH 8

General Info

  • Alternative names
    • Potentially prenylated protein tyrosine phosphatase
    • PRL 3
    • PRL R
    • PRL-3
    • PRL-R
    • PRL3
    • PRLR
    • Protein tyrosine phosphatase 4a3
    • Protein tyrosine phosphatase type IVA 3
    • Protein-tyrosine phosphatase 4a3
    • Protein-tyrosine phosphatase of regenerating liver 3
    • PTP 4A3
    • PTP4A3
    • TP4A3_HUMAN
    see all
  • FunctionProtein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
  • Tissue specificityMainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis.
  • Sequence similaritiesBelongs to the protein-tyrosine phosphatase family.
    Contains 1 tyrosine-protein phosphatase domain.
  • Post-translational
    modifications
    Farnesylated. Farnesylation is required for membrane targeting.
  • Cellular localizationCell membrane. Early endosome.
  • Information by UniProt

References for Recombinant Human PTP4A3 protein (ab42570)

ab42570 has not yet been referenced specifically in any publications.

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