Potentially prenylated protein tyrosine phosphatase
Protein tyrosine phosphatase 4a3
Protein tyrosine phosphatase type IVA 3
Protein-tyrosine phosphatase 4a3
Protein-tyrosine phosphatase of regenerating liver 3
FunctionProtein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
Tissue specificityMainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis.
Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Contains 1 tyrosine-protein phosphatase domain.
Post-translational modificationsFarnesylated. Farnesylation is required for membrane targeting.
Cellular localizationCell membrane. Early endosome.