The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activitySpecific Activity: 20 U/µg. One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C. Assay buffer: 50 mM HEPES, pH 7.4, 2 mM EDTA, 3mM DTT, 100 mM NaCl, 50 mM Pnpp, and 5µg/ml enzyme.
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Preparation and Storage
Stability and Storage
Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Cytoskeletal associated protein tyrosine phosphatase
Phosphatase with ezrin domain
Protein tyrosine phosphatase non receptor type 14
Protein tyrosine phosphatase pez
Protein-tyrosine phosphatase pez
Tyrosine protein phosphatase non receptor type 14
Tyrosine-protein phosphatase non-receptor type 14
FunctionProtein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis.
Tissue specificityExpressed in a variety of human tissues including kidney, skeletal muscle, lung and placenta.
Involvement in diseaseDefects in PTPN14 are a cause of choanal atresia and lymphedema (CHATLY) [MIM:613611]. A disease characterized by posterior choanal atresia and lymphedema. Additional features are a high-arched palate, hypoplastic nipples, and mild pectus excavatum. Note=A homozygous deletion in PTPN14 predicted to result in frameshift and premature truncation, has been shown to be the cause of choanal atresia and lymphedema in one family.
Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. Contains 1 FERM domain. Contains 1 tyrosine-protein phosphatase domain.
Post-translational modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.