Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • Amino acids817 to 1188

Specifications

Our Abpromise guarantee covers the use of ab42582 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activitySpecific Activity: 20 U/µg. One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C. Assay buffer: 50 mM HEPES, pH 7.4, 2 mM EDTA, 3mM DTT, 100 mM NaCl, 50 mM Pnpp, and 5µg/ml enzyme.
  • Applications

    Functional Studies

    Inhibition Assay

  • Purity> 90 % SDS-PAGE.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 50% Glycerol, 0.05% Tween 20, 75mM Sodium chloride, 25mM Tris HCl, 2mM EDTA, 10mM Glutathione, 1mM DTT, pH 8.0

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • Cytoskeletal associated protein tyrosine phosphatase
    • MGC126803
    • PEZ
    • Phosphatase with ezrin domain
    • Protein tyrosine phosphatase non receptor type 14
    • Protein tyrosine phosphatase pez
    • Protein-tyrosine phosphatase pez
    • PTN14_HUMAN
    • PTP 36
    • PTP36
    • PTPD 2
    • PTPN 14
    • PTPN14
    • Tyrosine protein phosphatase non receptor type 14
    • Tyrosine-protein phosphatase non-receptor type 14
    see all
  • FunctionProtein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis.
  • Tissue specificityExpressed in a variety of human tissues including kidney, skeletal muscle, lung and placenta.
  • Involvement in diseaseDefects in PTPN14 are a cause of choanal atresia and lymphedema (CHATLY) [MIM:613611]. A disease characterized by posterior choanal atresia and lymphedema. Additional features are a high-arched palate, hypoplastic nipples, and mild pectus excavatum. Note=A homozygous deletion in PTPN14 predicted to result in frameshift and premature truncation, has been shown to be the cause of choanal atresia and lymphedema in one family.
  • Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
    Contains 1 FERM domain.
    Contains 1 tyrosine-protein phosphatase domain.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationCytoplasm > cytoskeleton.
  • Information by UniProt

References for Recombinant human PTPD2 protein (ab42582)

ab42582 has not yet been referenced specifically in any publications.

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