Recombinant Human PTPIA2 / PTPRN protein (ab42590)

Overview

  • Product nameRecombinant Human PTPIA2 / PTPRN protein
  • Protein lengthFull length protein

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • Amino acids693 to 979

Specifications

Our Abpromise guarantee covers the use of ab42590 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Phosphatase Activity

  • Purity> 95 % SDS-PAGE.

  • FormLiquid
  • Additional notes


    This protein may be useful for the study of enzyme kinetics, regulation, and to dephosphorylate target substrates.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 50% Glycerol, 0.05% Tween 20, 75mM Sodium chloride, 25mM Tris HCl, 2mM EDTA, 10mM Glutathione, 1mM DTT, pH 8.0

General Info

  • Alternative names
    • CA 512
    • FLJ16131
    • IA 2
    • IA 2/PTP
    • IA2
    • IA2/PTP
    • ICA 3
    • ICA 512
    • ICA3
    • ICA512
    • Islet cell antigen 2
    • Islet cell antigen 512
    • Islet cell autoantigen 3
    • Protein tyrosine phosphatase like N
    • Protein tyrosine phosphatase like N precursor
    • Protein tyrosine phosphatase receptor type N
    • PTP IA 2
    • PTP IA-2
    • PTP IA2
    • PTPIA 2
    • PTPN
    • Ptprn
    • PTPRN protein
    • PTPRN_HUMAN
    • R PTP N
    • R-PTP-N
    • Receptor type tyrosine protein phosphatase like N
    • Receptor-type tyrosine-protein phosphatase-like N
    • RPTPN
    see all
  • FunctionImplicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.
  • Tissue specificityExpression is restricted to neuroendocrine cells. Found in pancreas, brain and pituitary.
  • Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
    Contains 1 tyrosine-protein phosphatase domain.
  • Post-translational
    modifications
    Appears to undergo multiple proteolytic cleavage at consecutive basic residues.
  • Cellular localizationMembrane. Neuroendocrine secretory granules.
  • Information by UniProt

References for Recombinant Human PTPIA2 / PTPRN protein (ab42590)

ab42590 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"