Overview

  • Product nameRecombinant human PTPN13 protein
  • Protein lengthProtein fragment

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • Amino acids2091 to 2490

Specifications

Our Abpromise guarantee covers the use of ab42581 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activitySpecific Activity: 5 U/µg. One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C. Assay buffer: 50 mM HEPES, pH 7.4, 2 mM EDTA, 3mM DTT, 100 mM NaCl, 50 mM pNPP. The specific activity of PTPN13 was determined using pNPP. Enzyme reaction condition: 20 mM pNPP, 5 min incubation at 30°C, 1µg enzyme.
  • Applications

    Inhibition Assay

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 50% Glycerol, 0.05% Tween 20, 75mM Sodium chloride, 25mM Tris HCl, 10mM Glutathione, 1mM DTT, pH 8.0

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • APO1/CD95 (Fas) associated phosphatase
    • DKFZp686J1497
    • FAP 1
    • FAP1
    • Fas associated phosphatase 1
    • Fas associated protein tyrosine phosphatase 1
    • HGNC:9646
    • hPTPE1
    • Phosphatase rip
    • PNP 1
    • PNP1
    • Protein tyrosine phosphatase 1 Fas associated
    • protein tyrosine phosphatase 1E
    • Protein tyrosine phosphatase non receptor type 13
    • Protein tyrosine phosphatase nonreceptor type 13
    • Protein tyrosine phosphatase PTPL1
    • protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
    • PTP BAS
    • PTP BL
    • PTP E1
    • PTP1E
    • PTPL 1
    • PTPL1
    • PTPLE
    • PTPN 13
    • PTPN13
    • Tyrosine protein phosphatase non receptor type 13
    see all
  • RelevancePTPN13 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as I-kappa-B-alpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway.
  • Cellular localizationCytoplasmic

References for Recombinant human PTPN13 protein (ab42581)

ab42581 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab42581.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"