Overview

  • Product name
    Recombinant human PTPN13 protein
  • Protein length
    Protein fragment

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human
    • Amino acids
      2091 to 2490

Specifications

Our Abpromise guarantee covers the use of ab42581 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Specific Activity: 5 U/µg. One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C. Assay buffer: 50 mM HEPES, pH 7.4, 2 mM EDTA, 3mM DTT, 100 mM NaCl, 50 mM pNPP. The specific activity of PTPN13 was determined using pNPP. Enzyme reaction condition: 20 mM pNPP, 5 min incubation at 30°C, 1µg enzyme.
  • Applications

    Inhibition Assay

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 50% Glycerol, 0.05% Tween 20, 75mM Sodium chloride, 25mM Tris HCl, 10mM Glutathione, 1mM DTT, pH 8.0

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • APO1/CD95 (Fas) associated phosphatase
    • DKFZp686J1497
    • FAP 1
    • FAP1
    • Fas associated phosphatase 1
    • Fas associated protein tyrosine phosphatase 1
    • HGNC:9646
    • hPTPE1
    • Phosphatase rip
    • PNP 1
    • PNP1
    • Protein tyrosine phosphatase 1 Fas associated
    • protein tyrosine phosphatase 1E
    • Protein tyrosine phosphatase non receptor type 13
    • Protein tyrosine phosphatase nonreceptor type 13
    • Protein tyrosine phosphatase PTPL1
    • protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
    • PTP BAS
    • PTP BL
    • PTP E1
    • PTP1E
    • PTPL 1
    • PTPL1
    • PTPLE
    • PTPN 13
    • PTPN13
    • Tyrosine protein phosphatase non receptor type 13
    see all
  • Relevance
    PTPN13 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as I-kappa-B-alpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway.
  • Cellular localization
    Cytoplasmic

References

ab42581 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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