Overview

  • Product nameRecombinant human PTPRB protein
  • Protein lengthProtein fragment

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • Amino acids1675 to 1996

Specifications

Our Abpromise guarantee covers the use of ab42583 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activitySpecific Activity: 40 U/µg. One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C. Assay buffer: 50 mM HEPES, pH 7.4, 2 mM EDTA, 3mM DTT, 100 mM NaCl, 50 mM pNPP.
  • Applications

    Inhibition Assay

    Functional Studies

  • Purity> 95 % SDS-PAGE.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 50% Glycerol, 0.05% Tween 20, 75mM Sodium chloride, 25mM Tris HCl, 2mM EDTA, 10mM Glutathione, 1mM DTT, pH 8.0

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • HPTP BETA
    • HPTPB
    • Phosphacan receptor type B
    • Protein tyrosine phosphatase receptor type B
    • Protein-tyrosine phosphatase beta
    • PTPB
    • Ptprb
    • PTPRB_HUMAN
    • R PTP BETA
    • R-PTP-beta
    • Receptor-type tyrosine-protein phosphatase beta
    • RPTPB
    • Vascular endothelial protein tyrosine phosphatase
    • VE-PTP
    see all
  • FunctionPlays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin.
  • Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
    Contains 17 fibronectin type-III domains.
    Contains 1 tyrosine-protein phosphatase domain.
  • Cellular localizationMembrane.
  • Information by UniProt

References for Recombinant human PTPRB protein (ab42583)

ab42583 has not yet been referenced specifically in any publications.

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