Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human
    • Molecular weight
      63 kDa including tags
    • Amino acids
      883 to 1210
    • Tags
      GST tag N-Terminus
    • Additional sequence information
      GeneBank Accession number: NM_130855

Associated products

Specifications

Our Abpromise guarantee covers the use of ab61149 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Functional Studies

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 30% Glycerol, 50mM Sodium chloride, 20mM MOPS, 0.25mM DTT, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • Protein tyrosine phosphatase PTPsigma
    • Protein tyrosine phosphatase receptor type S
    • Protein tyrosine phosphatase receptor type sigma
    • Ptprs
    • PTPRS_HUMAN
    • PTPSIGMA
    • R PTP sigma
    • R-PTP-S
    • R-PTP-sigma
    • Receptor-type tyrosine-protein phosphatase S
    • Receptor-type tyrosine-protein phosphatase sigma
    see all
  • Function
    Interacts with LAR-interacting protein LIP.1.
  • Tissue specificity
    Detected in all tissues tested except for placenta and liver.
  • Sequence similarities
    Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
    Contains 8 fibronectin type-III domains.
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 2 tyrosine-protein phosphatase domains.
  • Post-translational
    modifications
    A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization.
  • Cellular localization
    Membrane.
  • Information by UniProt

Recombinant human PTPRS protein images

  • Sample Kinase Activity Plot.
  • ab61149 on SDS-PAGE, MW ~63 kDa.

References for Recombinant human PTPRS protein (ab61149)

ab61149 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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