Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human
    • Molecular weight
      98 kDa including tags
    • Amino acids
      883 to 1501
    • Tags
      GST tag N-Terminus
    • Additional sequence information
      GenBank Accession No. BC104812

Specifications

Our Abpromise guarantee covers the use of ab90018 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Specific Activity: 223.2 pmol/min/mg. The specific activity of PTPRS was determined using pNPP. Enzyme reaction condition: 20 mM pNPP, 2 min incubation at 30°C, 1 ug enzyme. Assay buffer: 50 mM HEPES, pH 7.4, 2 mM EDTA, 3 mM DTT, 100 mM NaCl,50 mM pNPP.
  • Applications

    Functional Studies

    SDS-PAGE

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Store at -80°C.

    Preservative: None
    Constituents: 20% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8.0

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • Protein tyrosine phosphatase PTPsigma
    • Protein tyrosine phosphatase receptor type S
    • Protein tyrosine phosphatase receptor type sigma
    • Ptprs
    • PTPRS_HUMAN
    • PTPSIGMA
    • R PTP sigma
    • R-PTP-S
    • R-PTP-sigma
    • Receptor-type tyrosine-protein phosphatase S
    • Receptor-type tyrosine-protein phosphatase sigma
    see all
  • Function
    Interacts with LAR-interacting protein LIP.1.
  • Tissue specificity
    Detected in all tissues tested except for placenta and liver.
  • Sequence similarities
    Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
    Contains 8 fibronectin type-III domains.
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 2 tyrosine-protein phosphatase domains.
  • Post-translational
    modifications
    A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization.
  • Cellular localization
    Membrane.
  • Information by UniProt

Recombinant human PTPRS protein images

  • 10% SDS-PAGE analysis of 7µg ab90018.
  • Image showing specific activity of ab90018.

References for Recombinant human PTPRS protein (ab90018)

ab90018 has not yet been referenced specifically in any publications.

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