The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activitySpecific Activity: 223.2 pmol/min/mg.
The specific activity of PTPRS was determined using pNPP.
Enzyme reaction condition: 20 mM pNPP, 2 min incubation at 30°C, 1 ug enzyme.
Assay buffer: 50 mM HEPES, pH 7.4, 2 mM EDTA, 3 mM DTT, 100 mM NaCl,50 mM pNPP.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Protein tyrosine phosphatase PTPsigma
Protein tyrosine phosphatase receptor type S
Protein tyrosine phosphatase receptor type sigma
R PTP sigma
Receptor-type tyrosine-protein phosphatase S
Receptor-type tyrosine-protein phosphatase sigma
FunctionInteracts with LAR-interacting protein LIP.1.
Tissue specificityDetected in all tissues tested except for placenta and liver.
Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. Contains 8 fibronectin type-III domains. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 2 tyrosine-protein phosphatase domains.
Post-translational modificationsA cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization.