Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionQ03393
    • SpeciesHuman
    • SequenceMGSSHHHHHH SSGLVPRGSH MSTEGGGRRC QAQVSRRISF SASHRLYSKF LSDEENLKLF GKCNNPNGHG HNYKVVVTVH GEIDPATGMV MNLADLKKYM EEAIMQPLDH KNLDMDVPYF ADVVSTTENV AVYIWDNLQK VLPVGVLYKV KVYETDNNIV VYKGE.
    • Molecular weight19 kDa including tags
    • Amino acids1 to 145
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab116410 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 95 % SDS-PAGE.
    ab116410 was purified by proprietary chromatographic techniques and filter sterilized.
  • FormLiquid
  • Additional notesAlthough stable at 4°C for 4 weeks, ab116410 should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Please see notes section.

    pH: 8.00
    Constituents: 20% Glycerol, 0.32% Tris HCl, 0.02% DTT

General Info

  • Alternative names
    • 6 pyruvoyl tetrahydrobiopterin synthase
    • 6 pyruvoyl tetrahydropterin synthase
    • 6 pyruvoyltetrahydropterin synthase
    • 6-pyruvoyl tetrahydrobiopterin synthase
    • EC 4.2.3.12
    • FLJ97081
    • OTTHUMP00000235385
    • PTP synthase
    • PTPS
    • PTPS_HUMAN
    • PTS
    see all
  • FunctionInvolved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
  • PathwayCofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3.
  • Involvement in diseaseDefects in PTS are the cause of BH4-deficient hyperphenylalaninemia type A (HPABH4A) [MIM:261640]; also called 6-pyruvoyl-tetrahydropterin synthase deficiency (PTS deficiency) or hyperphenylalaninemia tetrahydrobiopterin-deficient due to PTS deficiency. HPABH4A is an autosomal recessive disorder characterized by depletion of the neurotransmitters dopamine and serotonin, and clinically by severe neurological symptoms unresponsive to the classic phenylalanine-low diet.
  • Sequence similaritiesBelongs to the PTPS family.
  • Post-translational
    modifications
    Phosphorylation of Ser-19 is required for maximal enzyme activity.
  • Information by UniProt

References for Recombinant Human PTS protein (ab116410)

ab116410 has not yet been referenced specifically in any publications.

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