Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MSTEGGGRRC QAQVSRRISF SASHRLYSKF LSDEENLKLF GKCNNPNGHG HNYKVVVTVH GEIDPATGMV MNLADLKKYM EEAIMQPLDH KNLDMDVPYF ADVVSTTENV AVYIWDNLQK VLPVGVLYKV KVYETDNNIV VYKGE

Specifications

Our Abpromise guarantee covers the use of ab92928 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 90 % SDS-PAGE.
    Purified using conventional chromatography techniques.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0

General Info

  • Alternative names
    • 6 pyruvoyl tetrahydrobiopterin synthase
    • 6 pyruvoyl tetrahydropterin synthase
    • 6 pyruvoyltetrahydropterin synthase
    • 6-pyruvoyl tetrahydrobiopterin synthase
    • EC 4.2.3.12
    • FLJ97081
    • OTTHUMP00000235385
    • PTP synthase
    • PTPS
    • PTPS_HUMAN
    • PTS
    see all
  • Function
    Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
  • Pathway
    Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3.
  • Involvement in disease
    Defects in PTS are the cause of BH4-deficient hyperphenylalaninemia type A (HPABH4A) [MIM:261640]; also called 6-pyruvoyl-tetrahydropterin synthase deficiency (PTS deficiency) or hyperphenylalaninemia tetrahydrobiopterin-deficient due to PTS deficiency. HPABH4A is an autosomal recessive disorder characterized by depletion of the neurotransmitters dopamine and serotonin, and clinically by severe neurological symptoms unresponsive to the classic phenylalanine-low diet.
  • Sequence similarities
    Belongs to the PTPS family.
  • Post-translational
    modifications
    Phosphorylation of Ser-19 is required for maximal enzyme activity.
  • Information by UniProt

Recombinant Human PTS protein images

  • 15% SDS-PAGE analysis of 3µg ab92928

References for Recombinant Human PTS protein (ab92928)

ab92928 has not yet been referenced specifically in any publications.

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