Recombinant Human PXR protein (ab82046)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • Amino acids138 to 434

Specifications

Our Abpromise guarantee covers the use of ab82046 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris Cl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 7.9

General Info

  • Alternative names
    • BXR
    • Nr1i2
    • NR1I2_HUMAN
    • Nuclear receptor subfamily 1 group I member 2
    • ONR 1
    • ONR1
    • Orphan nuclear receptor PAR 1
    • Orphan nuclear receptor PAR1
    • Orphan nuclear receptor PXR
    • OTTHUMP00000215173
    • OTTHUMP00000215174
    • OTTHUMP00000215175
    • PAR
    • PAR 1
    • PAR 2
    • PAR q
    • PAR1
    • PAR2
    • PARq
    • pregnane X nuclear receptor variant 2
    • Pregnane X receptor
    • PRR
    • PXR
    • SAR
    • Steroid and xenobiotic receptor
    • SXR
    see all
  • FunctionNuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.
  • Tissue specificityExpressed in liver, colon and small intestine.
  • Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Cellular localizationNucleus.
  • Information by UniProt

References for Recombinant Human PXR protein (ab82046)

ab82046 has not yet been referenced specifically in any publications.

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