Recombinant Human PXR protein (ab82082)

Overview

Description

  • NatureRecombinant
  • SourceBaculovirus
  • Amino Acid Sequence
    • SpeciesHuman

Associated products

Specifications

Our Abpromise guarantee covers the use of ab82082 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity1 unit equals 1 nanogram of purified protein. ab82082 binds to DNA as a heterodimer with RXR alpha; 1000U (1ug) required.
  • Applications

    EMSA

  • FormLiquid
  • Additional notes1 unit equals 1 nanogram of purified protein. ab82082 binds to DNA as a heterodimer with RXR alpha; 1000U (1ug) required.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris Cl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0

General Info

  • Alternative names
    • BXR
    • Nr1i2
    • NR1I2_HUMAN
    • Nuclear receptor subfamily 1 group I member 2
    • ONR 1
    • ONR1
    • Orphan nuclear receptor PAR 1
    • Orphan nuclear receptor PAR1
    • Orphan nuclear receptor PXR
    • OTTHUMP00000215173
    • OTTHUMP00000215174
    • OTTHUMP00000215175
    • PAR
    • PAR 1
    • PAR 2
    • PAR q
    • PAR1
    • PAR2
    • PARq
    • pregnane X nuclear receptor variant 2
    • Pregnane X receptor
    • PRR
    • PXR
    • SAR
    • Steroid and xenobiotic receptor
    • SXR
    see all
  • FunctionNuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.
  • Tissue specificityExpressed in liver, colon and small intestine.
  • Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Cellular localizationNucleus.
  • Information by UniProt

References for Recombinant Human PXR protein (ab82082)

ab82082 has not yet been referenced specifically in any publications.

Product Wall

Abreviews
Application Western blot
This product was used as a control protein for screening PXR antibodies and western blotting of cell lysates.
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Submitted Sep 03 2014

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"