Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab89816 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: 150mM Imidazole
    Constituents: 25% Glycerol, 50mM Sodium phosphate, 300mM Sodium chloride, 2mM DTT, 0.1mM PMSF, pH 7.0

General Info

  • Alternative names
    • OTTMUSP00000004488
    • p21 Rac3
    • p21-Rac3
    • Rac1B
    • RAC3
    • RAC3_HUMAN
    • RAS related C3 botulinum substrate 3
    • Ras related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3)
    • Ras related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
    • Ras-related C3 botulinum toxin substrate 3
    • Rho family small GTP binding protein Rac3
    • RP23-84C12.18
    see all
  • FunctionPlasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner.
  • Tissue specificityHighest levels in brain, also detected in heart, placenta and pancreas.
  • Sequence similaritiesBelongs to the small GTPase superfamily. Rho family.
  • Post-translational
    modifications
    (Microbial infection) Glycosylated at Tyr-32 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rac and leads to actin disassembly.
  • Cellular localizationCytoplasm. Endomembrane system. Cell projection, lamellipodium. Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton. Membrane-associated when activated. Colocalizes with NRBP to endomembranes and at the cell periphery in lamellipodia. Colocalized with CIB1 in the perinuclear area and at the cell periphery.
  • Information by UniProt

Recombinant Human RAC3 protein images

  • SDS-PAGE showing ab89816 at approximately 24kDa.

References for Recombinant Human RAC3 protein (ab89816)

ab89816 has not yet been referenced specifically in any publications.

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