Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionO60671
    • SpeciesHuman
    • SequenceMGSSHHHHHH SSGLVPRGSH MPLLTQQIQD EDDQYSLVAS LDNVRNLSTI LKAIHFREHA TCFATKNGIK VTVENAKCVQ ANAFIQAGIF QEFKVQEESV TFRINLTVLL DCLSIFGSSP MPGTLTALRM CYQGYGYPLM LFLEEGGVVT VCKINTQEPE ETLDFDFCST NVINKIILQS EGLREAFSEL DMTSEVLQIT MSPDKPYFRL STFGNAGSSH LDYPKDSDLM EAFHCNQTQV NRYKISLLKP STKALVLSCK VSIRTDNRGF LSLQYMIRNE DGQICFVEYY CCPDEEVPES ES
    • Molecular weight34 kDa including tags
    • Amino acids1 to 282
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab123485 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 90 % SDS-PAGE.
    ab123485 was purified by proprietary chromatographic techniques and filter sterilized.
  • FormLiquid
  • Additional notesPlease prevent freeze thaw cycles.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Store under Desiccating conditions.

    pH: 8.00
    Constituents: 0.02% DTT, 0.24% Tris, 10% Glycerol, 1.17% Sodium chloride

General Info

  • Alternative names
    • Cell cycle checkpoint protein Hrad1
    • Cell cycle checkpoint protein Rad 1 A / B
    • Cell cycle checkpoint protein RAD1
    • Checkpoint control protein HRAD1
    • Checkpoint control protein RAD1
    • DNA repair exonuclease
    • DNA repair exonuclease rad1
    • DNA repair exonuclease rad1 homolog
    • DNA repair exonuclease REC1
    • DNA repair protein RAD1
    • EC 3.1.11.2
    • Exonuclease homolog RAD1
    • GTP-binding protein RAD
    • hRAD 1
    • hRAD1
    • MGC77779
    • RAD
    • RAD 1
    • RAD1
    • RAD1 homolog
    • RAD1 homolog (S. pombe)
    • Rad1 like DNA damage checkpoint
    • Rad1 like DNA damage checkpoint protein
    • RAD1, S. pombe, homolog of
    • Rad1-like DNA damage checkpoint protein
    • RAD1_HUMAN
    • Ras associated with diabetes
    • REC 1
    • REC1
    • RRAD
    see all
  • FunctionComponent of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. Isoform 1 possesses 3'->5' double stranded DNA exonuclease activity.
  • Tissue specificityExpressed in testis, uterus, bladder, spleen, ovaries, lung, brain and muscle (at protein level).
  • Sequence similaritiesBelongs to the rad1 family.
  • Cellular localizationNucleus.
  • Information by UniProt

References for Recombinant Human Rad1 protein (ab123485)

ab123485 has not yet been referenced specifically in any publications.

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