Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Molecular weight
      83 kDa including tags
    • Amino acids
      1 to 495

Specifications

Our Abpromise guarantee covers the use of ab112417 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    useful for Antibody Production and Protein Array
  • Applications

    SDS-PAGE

    Western blot

    ELISA

  • Form
    Liquid
  • Additional notes
    Best use within three months from the date of receipt of this protein.useful for Antibody Production and Protein Array
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: (Glutathione is reduced)

General Info

  • Alternative names
    • 2810024C04Rik
    • DNA repair protein rad18
    • E3 ubiquitin-protein ligase RAD18
    • EC 6.3.2.-
    • hHR 18
    • hHR18
    • hRAD 18
    • hRAD18
    • MGC156682
    • Postreplication repair E3 ubiquitin-protein ligase RAD18
    • Postreplication repair protein hRAD18p
    • Postreplication repair protein RAD18
    • RAD 18
    • RAD18
    • RAD18 homolog
    • RAD18 homolog (S. cerevisiae)
    • RAD18 S. cerevisiae homolog
    • RAD18 S. cerevisiae homolog of
    • RAD18 transcript variant
    • RAD18_HUMAN
    • Rad18sc
    • Radiation sensitivity protein 18
    • RING finger protein 73
    • RNF 73
    • RNF73
    • Structural maintenance of chromosomes protein 6
    • YCR066W
    • YCR66W
    see all
  • Function
    E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity.
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Belongs to the RAD18 family.
    Contains 1 RING-type zinc finger.
    Contains 1 SAP domain.
    Contains 1 UBZ-type zinc finger.
  • Cellular localization
    Nucleus.
  • Information by UniProt

Images

  • 12.5% SDS-PAGE Stained with Coomassie Blue.

References

ab112417 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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