Recombinant Human Radixin protein (ab114380)

Overview

  • Product nameRecombinant Human Radixin protein
  • Protein lengthFull length protein

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionP35241
    • SpeciesHuman
    • SequenceMPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYV DSKGYSTWLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQR LFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPGYLAND RLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQDLEM YGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISF NDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTI EVQQMKAQAREEKHQKQLERAQLENEKEKREIAEKEKERIEREKEELMER LKQIEEQTIKAQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAK SAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEEEATEWQHKAF AAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENEHDEHDENNAEASAEL SNEGVMNHRSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVL HAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM
    • Molecular weight90 kDa including tags
    • Amino acids1 to 583

Specifications

Our Abpromise guarantee covers the use of ab114380 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
    ab114380 is best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

General Info

  • Alternative names
    • CB567
    • CG12537
    • DFNB24
    • ESP10
    • Hh-induced MATH and BTB domain-containing protein
    • HIB
    • Moesin-B
    • Protein roadkill
    • RADI_HUMAN
    • Radixin
    • RDX
    see all
  • FunctionProbably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.
  • Involvement in diseaseDefects in RDX are the cause of deafness autosomal recessive type 24 (DFNB24) [MIM:611022]. DFNB24 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
  • Sequence similaritiesContains 1 FERM domain.
  • DomainThe N-terminal domain interacts with the C-terminal domain of LAYN. An interdomain interaction between its N-terminal and C-terminal domains inhibits its ablilty to bind LAYN. In the presence of acidic phospholipids, the interdomain interaction is inhibited and this enhances binding to LAYN.
  • Post-translational
    modifications
    Phosphorylated by tyrosine-protein kinases.
  • Cellular localizationCell membrane. Cytoplasm > cytoskeleton. Cleavage furrow. Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively.
  • Information by UniProt

Recombinant Human Radixin protein images

  • ab114380 analysed on a 12.5% SDS-PAGE Stained with Coomassie Blue.

References for Recombinant Human Radixin protein (ab114380)

ab114380 has not yet been referenced specifically in any publications.

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