The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Dopamine receptor interacting protein 5
Dopamine receptor-interacting protein 5
RAP1, yeast, homolog if
RAP1, yeast, homolog of
Repressor/activator protein 1 homolog
Telomeric Repeat Binding Factor 2 Interacting Protein
Telomeric repeat-binding factor 2-interacting protein 1
TERF2-interacting telomeric protein 1
TRF2 Interacting Telomeric Protein RAP1
TRF2 interacting telomeric RAP1 protein
TRF2-interacting telomeric protein
TRF2-interacting telomeric protein 1
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.
Ubiquitous. Highly expressed.
Belongs to the RAP1 family. Contains 1 BRCT domain. Contains 1 Myb-like domain.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Nucleus. Cytoplasm. Chromosome. Chromosome > telomere. Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex.