FunctionSmall GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells.
Tissue specificityExpressed in red blood cells (at protein level).
Sequence similaritiesBelongs to the small GTPase superfamily. Ras family.
DomainThe effector domain mediates the interaction with RUNDC3A.
Post-translational modificationsPalmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK.
Cellular localizationRecycling endosome membrane. Associated with red blood cells-released vesicles.