The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityImmune reactive in ELISA using monoclonal anti-CD4 in gpl2O capture ELISA assays.
% SDS-PAGE. Purity is greater than 95% by HPLC and SDS-PAGE.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20ºC.
pH: 7.40 Constituent: PBS
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Plasma retinol binding protein 4
Plasma retinol-binding protein
Plasma retinol-binding protein(1-176)
Retinol binding protein 4
Retinol binding protein 4 interstitial
Retinol binding protein 4 plasma
FunctionDelivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
Involvement in diseaseDefects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:180250]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium.
Sequence similaritiesBelongs to the calycin superfamily. Lipocalin family.