ReconstitutionAdd deionized water to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely.
Islet cells regeneration factor
Islet of Langerhans regenerating protein
Lithostathine 1 alpha
Lithostathine 1 alpha precursor
Pancreatic stone protein
Pancreatic stone protein secretory
Pancreatic thread protein
Regenerating islet derived 1 alpha
Regenerating islet derived 1 alpha pancreatic stone protein pancreatic thread protein
Regenerating islet-derived protein 1-alpha
Regenerating protein I alpha
FunctionMight act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.
Tissue specificityIn pancreatic acinar cells and, in lower levels, in brain. Enhanced expression of PSP-related transcripts and intraneuronal accumulation of PSP-like proteins is found in brain from Alzheimer disease and Down syndrome patients.
Developmental stageHigh expression levels in fetal and infant brains; much lower in adult brains.
Post-translational modificationsThe composition of the O-linked carbohydrate on Thr-27 is complex and varied. In the crystallographic structure, the attached sugar appears to be N-acetylglucosamine, typical of an intracellular protein, rather than N-acetylgalactosamine.