Additional sequence informationThe Recombinant Human REG3A protein is produced with N-terminal fusion of His Tag. The REG3A His -Tagged Fusion Protein is an 18.4 kDa protein containing 149 amino acid residues
ReconstitutionAdd 0.2 ml of 0.1M Acetate buffer pH-4 and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10µg/ml. In higher concentrations the solubility of this antigen is limited.
Hepatocarcinoma intestine pancreas
Hepatointestinal pancreatic protein
Human proislet peptide
Pancreatic beta cell growth factor
Pancreatitis associated protein
Pancreatitis associated protein 1
Pancreatitis-associated protein 1
PAP homologous protein
Proliferation inducing protein 34
Proliferation inducing protein 42
Reg III alpha
Regenerating islet derived 3 alpha
Regenerating islet derived protein 3 alpha precursor
Regenerating islet-derived protein 3-alpha 15 kDa form
Regenerating islet-derived protein III-alpha
FunctionBactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.
Tissue specificityHighly expressed in epidermal keratinocytes of psoriasis patients (at protein level). Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis.
DomainThe EPN motif is essential for recognition of the peptidoglycan carbohydrate backbone and for efficient bacterial killing with Glu-114 playing a key role in peptidoglycan binding and bactericidal activity.
Post-translational modificationsProteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.
Cellular localizationSecreted. Found in the apical region of pancreatic acinar cells.