Ras related and estrogen regulated growth inhibitor
Ras-related and estrogen-regulated growth inhibitor
Weakly similar to N ras protein [H.sapiens]
FunctionBinds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential.
Tissue specificityDetected in heart, brain, placenta, lung, liver, skin, kidney and pancreas. Detected in estrogen receptor-positive breast-derived cell lines, but not in estrogen receptor-negative cell lines. Expression is decreased or lost in a significant proportion of primary breast tumors with poor clinical prognosis.
Sequence similaritiesBelongs to the small GTPase superfamily. Ras family.