Recombinant Human Retinoic Acid Receptor beta protein (ab81841)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab81841 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 95 % SDS-PAGE.
    ab81841 was expressed in a bacterial system and purified by an affinity column in combination with FPLC chromatography it showed greater than 95% homogeneous and contains no detectable protease, DNase and RNase activity.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris HCl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8

General Info

  • Alternative names
    • HAP
    • HBV-activated protein
    • NR1B2
    • Nuclear receptor subfamily 1 group B member 2
    • RAR B
    • RAR beta
    • RAR epsilon
    • RAR-beta
    • RAR-epsilon
    • RARB
    • RARB_HUMAN
    • Retinoic acid receptor beta
    • Retinoic acid receptor beta 2
    • Retinoic acid receptor beta 4
    • Retinoic acid receptor beta 5
    • Retinoic acid receptor beta polypeptide
    • RRB2
    see all
  • FunctionReceptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
  • Involvement in diseaseMicrophthalmia, syndromic, 12
  • Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • Cellular localizationCytoplasm and Nucleus.
  • Information by UniProt

References for Recombinant Human Retinoic Acid Receptor beta protein (ab81841)

ab81841 has not yet been referenced specifically in any publications.

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