Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MGSHMRAAAI STPKLDKMPG MFFSANPKEL KGTTHSLLDD KMQKRRPKTF GMDMKAYLRS MIPHLESGMK SSKSKDVLSA AEVMQWSQSL EKLLANQTGQ NVFGSFLKSE FSEENIEFWL ACEDYKKTES DLLPCKAEEI YKAFVHSDAA KQINIDFRTR ESTAKKIKAP TPTCFDEAQK VIYTLMEKDS YPRFLKSDIY LNLLNDLQAN SLK
    • Molecular weight
      26 kDa including tags
    • Amino acids
      1 to 209
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab126697 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF
  • Purity
    > 90 % SDS-PAGE.
    ab126697 is purified by conventional chromatography techniques.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 10% Glycerol, 0.88% Sodium chloride

General Info

  • Alternative names
    • 1R20
    • B cell activation protein BL34
    • B-cell activation protein BL34
    • BL34
    • Early response protein 1R20
    • IER 1
    • IER1
    • Immediate early response 1 B cell specific
    • immediate-early response 1, B-cell specific
    • IR20
    • Regulator of G protein signalling 1
    • Regulator of G-protein signaling 1
    • RGS 1
    • RGS1
    • RGS1_HUMAN
    see all
  • Function
    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation.
  • Tissue specificity
    B-cell specific. Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high.
  • Sequence similarities
    Contains 1 RGS domain.
  • Post-translational
    modifications
    Could be phosphorylated. Might be functionally regulated by protein kinase(s).
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of 3 µg of ab126697 (RGS1 protein).

References

ab126697 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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