Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MCRTLAAFPT TCLERAKEFK TRLGIFLHKS ELGCDTGSTG KFEWGSKHSK ENRNFSEDVL GWRESFDLLL SSKNGVAAFH AFLKTEFSEE NLEFWLACEE FKKIRSATKL ASRAHQIFEE FICSEAPKEV NIDHETRELT RMNLQTATAT CFDAAQGKTR TLMEKDSYPR FLKSPAYRDL AAQASAASAT LSSCSLDEPS HT
    • Amino acids
      1 to 202
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab93733 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 90 % SDS-PAGE.
    Purified using conventional chromatography techniques.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 20% Glycerol, PBS, 100mM Sodium chloride, pH 7.4

General Info

  • Alternative names
    • A28 RGS14
    • A28 RGS14P
    • A28-RGS14P
    • HGNC:9997
    • hRGS-r
    • OTTHUMP00000033147
    • Regulator of G protein signaling 16
    • Regulator of G protein signalling 16
    • Regulator of G-protein signaling 16
    • Retinal-specific RGS
    • Retinally abundant regulator of G protein signaling
    • Retinally abundant regulator of G-protein signaling
    • RGS 16
    • RGS R
    • RGS-R
    • Rgs14
    • RGS16
    • RGS16_HUMAN
    • RGSR
    see all
  • Function
    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. May play a role in regulating the kinetics of signaling in the phototransduction cascade.
  • Tissue specificity
    Abundantly expressed in retina with lower levels of expression in most other tissues.
  • Sequence similarities
    Contains 1 RGS domain.
  • Post-translational
    modifications
    Palmitoylated on Cys-2 and/or Cys-12.
    Phosphorylation on Tyr-168 upon EGFR stimulation. Enhanced GTPase accelerating (GAP) activity on G(i)-alpha.
  • Information by UniProt

Images

  • 15% SDS Page analysis of 3ug ab93733

References

ab93733 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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