Guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein
Regulator of G protein signalling 19
Regulator of G-protein signaling 19
FunctionInhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
Tissue specificityHighest expression in lung. Placenta, liver and heart also express high levels of GAIP.
Sequence similaritiesContains 1 RGS domain.
Post-translational modificationsFatty acylated. Heavily palmitoylated in the cysteine string motif. Phosphorylated, mainly on serine residues.