Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman

Associated products

Specifications

Our Abpromise guarantee covers the use of ab75333 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

    SDS-PAGE

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5

General Info

  • Alternative names
    • G alpha interacting protein
    • G protein signalling regulator 19
    • G protein, alpha-interacting protein
    • G-alpha-interacting protein
    • GAIP
    • GNAI3IP
    • Guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein
    • Regulator of G protein signalling 19
    • Regulator of G-protein signaling 19
    • RGS19
    • RGS19_HUMAN
    • RGSGAIP
    see all
  • FunctionInhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
  • Tissue specificityHighest expression in lung. Placenta, liver and heart also express high levels of GAIP.
  • Sequence similaritiesContains 1 RGS domain.
  • Post-translational
    modifications
    Fatty acylated. Heavily palmitoylated in the cysteine string motif.
    Phosphorylated, mainly on serine residues.
  • Cellular localizationMembrane.
  • Information by UniProt

Recombinant Human RGS19 protein images

  • SDS Page analysis of ab75333

References for Recombinant Human RGS19 protein (ab75333)

ab75333 has not yet been referenced specifically in any publications.

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