This product is an active protein and may elicit a biological response in vivo, handle with caution.
GATA-3-binding protein G3B
Lysine N-methyltransferase 8
PR domain containing 2, with ZNF domain
PR domain zinc finger protein 2
PR domain-containing protein 2
Retinoblastoma protein binding zinc finger protein
Retinoblastoma protein-interacting zinc finger protein
Retinoblastoma protein-interacting zinc-finger protein
Zinc finger DNA binding protein
Zinc finger protein RIZ
FunctionS-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.
Tissue specificityHighly expressed in retinoblastoma cell lines and in brain tumors. Also expressed in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen. Isoform 1 is expressed in testis at much higher level than isoform 3.
Sequence similaritiesContains 8 C2H2-type zinc fingers. Contains 1 SET domain.