DNA directed RNA polymerase II 14.5 kDa polypeptide
DNA directed RNA polymerase II polypeptide I
DNA directed RNA polymerase II subunit I
DNA directed RNA polymerase II subunit RPB9
DNA-directed RNA polymerase II subunit I
DNA-directed RNA polymerase II subunit RPB9
Polymerase (RNA) II (DNA directed) polypeptide I 14.5kDa
RNA polymerase II 14.5 kDa subunit
RNA polymerase II subunit B9
FunctionDNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template.
Sequence similaritiesBelongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. Contains 1 TFIIS-type zinc finger.
Post-translational modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.