The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
E3 ubiquitin protein ligase RNF138
E3 ubiquitin-protein ligase RNF138
Nemo like kinase associated RING finger protein
Nemo-like kinase-associated RING finger protein
NLK associated RING finger protein
NLK-associated RING finger protein
RING finger protein 138
ring finger protein 138, E3 ubiquitin protein ligase
E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.
Protein modification; protein ubiquitination.
Contains 1 RING-type zinc finger.
The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
Auto-ubiquitinated. Phosphorylated upon DNA damage, probably by ATM or ATR.