Overview

Description

  • Nature
    Recombinant
  • Source
    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Species
      Human
    • Amino acids
      983 to 1400

Associated products

Specifications

Our Abpromise guarantee covers the use of ab70541 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Specific activity was determined to be 81nmol/min/mg.
  • Applications

    Functional Studies

    SDS-PAGE

  • Form
    Liquid
  • Additional notes

    ab204853 (IRS1 peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • c met related tyrosine kinase
    • CD136
    • CD136 antigen
    • CDw136
    • Macrophage stimulating 1 receptor
    • Macrophage stimulating 1 receptor (c met related tyrosine kinase)
    • MACROPHAGE STIMULATING PROTEIN RECEPTOR
    • Macrophage stimulating protein receptor alpha chain
    • Macrophage stimulating protein receptor beta chain
    • Macrophage-Stimulating 1 Receptor (MST1R)
    • Macrophage-stimulating protein receptor beta chain
    • MSP receptor
    • Mst1r
    • MST1R variant RON30
    • MST1R variant RON62
    • NPCA3
    • p185 RON
    • p185-Ron
    • Protein-tyrosine kinase 8
    • PTK 8
    • ptk8
    • PTK8 protein tyrosine kinase 8
    • Recepteur d’origine nantais (RON)
    • RON
    • RON protein tyrosine kinase
    • RON variant E2E3
    • RON_HUMAN
    • Soluble RON variant 1
    • Soluble RON variant 2
    • Soluble RON variant 3
    • Soluble RON variant 4
    • Stem cell derived tyrosine kinase
    see all
  • Function
    Receptor for macrophage stimulating protein (MSP). Has a tyrosine-protein kinase activity.
  • Tissue specificity
    Keratinocytes and lung.
  • Sequence similarities
    Belongs to the protein kinase superfamily. Tyr protein kinase family.
    Contains 3 IPT/TIG domains.
    Contains 1 protein kinase domain.
    Contains 1 Sema domain.
  • Post-translational
    modifications
    Proteolytic processing yields the two subunits.
    Phosphorylated in response to ligand binding.
  • Cellular localization
    Membrane.
  • Information by UniProt

Images

  • SDS-PAGE showing ab70541 at approximately 71kDa.
  • Kinase Assay demonstrating Specific activity was determined to be 81nmol/min/mg.

References

ab70541 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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