Overview

Description

  • NatureRecombinant
  • SourceBaculovirus infected Sf9 cells
  • Amino Acid Sequence
    • SpeciesHuman
    • Amino acids427 to 943

Associated products

Specifications

Our Abpromise guarantee covers the use of ab70614 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    SDS-PAGE

  • FormLiquid
  • Additional notes

    ab64311 (Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • BDB
    • BDB1
    • Brachydactyly type B
    • EC 2.7.10.1
    • MGC163394
    • Neurotrophic tyrosine kinase
    • Neurotrophic tyrosine kinase, receptor related 2
    • NTRKR2
    • Receptor tyrosine kinase-like orphan receptor 2
    • receptor-related 2
    • ROR2
    • ROR2_HUMAN
    • Tyrosine protein kinase transmembrane receptor ROR2
    • Tyrosine-protein kinase transmembrane receptor Ror2
    see all
  • FunctionTyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation.
  • Involvement in diseaseBrachydactyly B1
    Robinow syndrome autosomal recessive
  • Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
    Contains 1 FZ (frizzled) domain.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 kringle domain.
    Contains 1 protein kinase domain.
  • Developmental stageExpressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.
  • Cellular localizationCell membrane.
  • Information by UniProt

Recombinant human ROR2 protein images

  • Kinase assay
  • SDS-PAGE showing ab70614 at approximately 86kDa.

References for Recombinant human ROR2 protein (ab70614)

ab70614 has not yet been referenced specifically in any publications.

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