This product is an active protein and may elicit a biological response in vivo, handle with caution.
c ros 1
c ros oncogene 1 receptor tyrosine kinase
c Ros receptor tyrosine kinase
Proto oncogene c Ros
Proto oncogene c ros 1 protein
Proto oncogene tyrosine protein kinase ROS
Proto oncogene tyrosine protein kinase ROS precursor
Proto-oncogene tyrosine-protein kinase ROS
Receptor tyrosine kinase c ros oncogene 1
ROS proto oncogene 1 , receptor tyrosine kinase
Transmembrane tyrosine specific protein kinase
v ros avian UR2 sarcoma virus oncogene homolog 1
v ros UR2 sarcoma virus oncogene homolog 1
FunctionThis is probably a cell growth or differentiation factor receptor with a tyrosine-protein kinase activity.
Tissue specificityExpressed in brain. Expression is increased in primary gliomas.
Involvement in diseaseNote=A chromosomal aberration involving ROS1 is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.
Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 9 fibronectin type-III domains. Contains 1 protein kinase domain.