Overview

Description

  • Nature
    Recombinant
  • Source
    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Molecular weight
      82 kDa including tags
    • Amino acids
      1883 to 2347

Specifications

Our Abpromise guarantee covers the use of ab125624 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    The specific activity of ab125624 was determined to be 640 nmol/min/mg.
  • Applications

    Western blot

    Functional Studies

    SDS-PAGE

  • Form
    Liquid
  • Additional notes

    ab204862 (IRS1 peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.003% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • c ros
    • c ros 1
    • c ros oncogene 1 receptor tyrosine kinase
    • c Ros receptor tyrosine kinase
    • c ros1
    • MCF 3
    • MCF3
    • Oncogene ROS
    • OTTHUMP00000017814
    • OTTHUMP00000017815
    • OTTHUMP00000040389
    • Proto oncogene c Ros
    • Proto oncogene c ros 1 protein
    • Proto oncogene tyrosine protein kinase ROS
    • Proto oncogene tyrosine protein kinase ROS precursor
    • Proto-oncogene c-Ros-1
    • Proto-oncogene tyrosine-protein kinase ROS
    • Receptor tyrosine kinase c ros oncogene 1
    • ROS
    • Ros 1
    • ROS 1C
    • ROS proto oncogene 1 , receptor tyrosine kinase
    • ROS_HUMAN
    • ROS1
    • ROS1C
    • Transmembrane tyrosine specific protein kinase
    • v ros avian UR2 sarcoma virus oncogene homolog 1
    • v ros UR2 sarcoma virus oncogene homolog 1
    see all
  • Function
    This is probably a cell growth or differentiation factor receptor with a tyrosine-protein kinase activity.
  • Tissue specificity
    Expressed in brain. Expression is increased in primary gliomas.
  • Involvement in disease
    Note=A chromosomal aberration involving ROS1 is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.
  • Sequence similarities
    Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
    Contains 9 fibronectin type-III domains.
    Contains 1 protein kinase domain.
  • Cellular localization
    Membrane.
  • Information by UniProt

Images

  • Sample Kinase Assay showing the specific activity of ab125624 as 640 nmol/min/mg.
  • SDS-PAGE analysis of ab125624.

References

ab125624 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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