Overview

  • Product name
    Recombinant Human RRM2 protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MLSLRVPLAP ITDPQQLQLS PLKGLSLVDK ENTPPALSGT RVLASKTARR IFQEPTEPKT KAAAPGVEDEPLLRENPRRF VIFPIEYHDI WQMYKKAEAS FWTAEEVDLS KDIQHWESLK PEERYFISHV LAFFAASDGI VNENLVERFS QEVQITEARC FYGFQIAMEN IHSEMYSLLI DTYIKDPKER EFLFNAIETM PCVKKKADWA LRWIGDKEAT YGERVVAFAA VEGIFFSGSF ASIFWLKKRGLMPGLTFSNE LISRDEGLHC DFACLMFKHL VHKPSEERVR EIIINAVRIE QEFLTEALPV KLIGMNCTLM KQYIEFVADR LMLELGFSKV FRVENPFDFM ENISLEGKTN FFEKRVGEYQ RMGVMSSPTE NSFTLDADF
    • Molecular weight
      47 kDa including tags
    • Amino acids
      1 to 389
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab99137 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF
  • Purity
    >= 85 % SDS-PAGE.
    ab99137 was purified using conventional chromatography techniques.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 10% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, pH 8

General Info

  • Alternative names
    • cb111
    • chunp6884
    • etID309896.20
    • R2
    • reductase M2 polypeptide variant 1
    • reductase M2 polypeptide variant 2
    • reductase M2 polypeptide variant 3a
    • reductase M2 polypeptide variant 3b
    • reductase M2 polypeptide variant 3c
    • reductase M2 polypeptide variant 3d
    • Ribonucleoside-diphosphate reductase subunit M2
    • Ribonucleotide reductase M2
    • Ribonucleotide reductase M2 polypeptide
    • Ribonucleotide reductase M2 subunit
    • ribonucleotide reductase protein r2 class I
    • Ribonucleotide reductase regulatory subunit M2
    • Ribonucleotide reductase small chain
    • Ribonucleotide reductase small subunit
    • Ribonucleotide reductase, R2 subunit
    • RIR2_HUMAN
    • RR2
    • RR2M
    • RRM2
    see all
  • Function
    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
  • Pathway
    Genetic information processing; DNA replication.
  • Sequence similarities
    Belongs to the ribonucleoside diphosphate reductase small chain family.
  • Post-translational
    modifications
    Phosphorylation on Ser-20 relieves the inhibitory effect on Wnt signaling.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab99137 (3ug)

References

ab99137 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab99137.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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