The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
90 kDa ribosomal protein S6 kinase 3
Insulin stimulated protein kinase 1
Insulin-stimulated protein kinase 1
MAP kinase activated protein kinase 1b
MAP kinase-activated protein kinase 1b
MAPK activated protein kinase 1b
MAPK-activated protein kinase 1b
MAPKAP kinase 1b
Mental retardation, X linked 19
Ribosomal protein S6 kinase 90kDa polypeptide 3
Ribosomal protein S6 kinase alpha 3
Ribosomal protein S6 kinase alpha-3
Ribosomal protein s6 kinase ii alpha 2
Ribosomal S6 kinase 2
S6 kinase 2
Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.
Expressed in many tissues, highest levels in skeletal muscle.
Involvement in disease
Defects in RPS6KA3 are the cause of Coffin-Lowry syndrome (CLS) [MIM:303600]; an X-linked dominant disorder characterized by severe mental retardation with facial and digital dysmorphisms, and progressive skeletal deformations.
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 2 protein kinase domains.
Autophosphorylated on Ser-386, as part of the activation process. Ser-227 phosphorylation promotes Ser-386 phosphorylation and leads to basal activation. Full activation by growth factors requires additional phosphorylation on Ser-369.