This product is an active protein and may elicit a biological response in vivo, handle with caution.
90 kDa ribosomal protein S6 kinase 3
Insulin stimulated protein kinase 1
Insulin-stimulated protein kinase 1
MAP kinase activated protein kinase 1b
MAP kinase-activated protein kinase 1b
MAPK activated protein kinase 1b
MAPK-activated protein kinase 1b
MAPKAP kinase 1b
Mental retardation, X linked 19
Ribosomal protein S6 kinase 90kDa polypeptide 3
Ribosomal protein S6 kinase alpha 3
Ribosomal protein S6 kinase alpha-3
Ribosomal protein s6 kinase ii alpha 2
Ribosomal S6 kinase 2
S6 kinase 2
FunctionSerine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.
Tissue specificityExpressed in many tissues, highest levels in skeletal muscle.
Involvement in diseaseDefects in RPS6KA3 are the cause of Coffin-Lowry syndrome (CLS) [MIM:303600]; an X-linked dominant disorder characterized by severe mental retardation with facial and digital dysmorphisms, and progressive skeletal deformations.
Sequence similaritiesBelongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 2 protein kinase domains.
Post-translational modificationsAutophosphorylated on Ser-386, as part of the activation process. Ser-227 phosphorylation promotes Ser-386 phosphorylation and leads to basal activation. Full activation by growth factors requires additional phosphorylation on Ser-369.