This product is an active protein and may elicit a biological response in vivo, handle with caution.
90 kDa ribosomal protein S6 kinase 2
MAP kinase activated protein kinase 1c
MAP kinase-activated protein kinase 1c
MAPK-activated protein kinase 1c
MAPKAP kinase 1c
Mitogen.activated protein kinase-activated protein kinase 1C
Ribosomal protein S6 kinase alpha-2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
Ribosomal S6 kinase 3
S6K alpha 2
FunctionSerine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.
Tissue specificityWidely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.
Sequence similaritiesBelongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 2 protein kinase domains.
Post-translational modificationsActivated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1. N-terminal myristoylation results in an activated kinase in the absence of added growth factors.