The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
FYVE finger protein EIP1
FYVE-finger protein EIP1
La binding protein 1
La-binding protein 1
Rab4 interacting protein
RUN and FYVE domain containing 1
RUN and FYVE domain-containing protein 1
RUN and FYVE domains containing protein 1
Zinc finger FYVE domain containing protein 12
Zinc finger FYVE domain-containing protein 12
Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking.
Broadly expressed, with highest levels in lung, testis, kidney and brain.
Contains 1 FYVE-type zinc finger. Contains 1 RUN domain.
The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is substantially increased in acidic conditions.
Phosphorylation on Tyr-389 and/or Tyr-400 is required for interaction with BMX and endosomal targeting. Phosphorylated upon DNA damage, probably by ATM or ATR.