Polyomavirus enhancer binding protein 2 alpha C subunit
Polyomavirus enhancer-binding protein 2 alpha C subunit
runt domain alpha subunit 3
runt related transcription factor 3
Runt-related transcription factor 3
SL3 3 enhancer factor 1 alpha C subunit
SL3-3 enhancer factor 1 alpha C subunit
SL3/AKV core binding factor alpha C subunit
SL3/AKV core-binding factor alpha C subunit
Transcription factor AML2
FunctionCBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters.
Sequence similaritiesContains 1 Runt domain.
DomainA proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes.
Post-translational modificationsPhosphorylated on tyrosine residues by SRC. Phosphorylated by LCK and FYN.
Cellular localizationNucleus. Cytoplasm. The tyrosine phosphorylated form localizes to the cytoplasm.