Overview

  • Product nameRecombinant Human RUNX3 protein
  • Protein lengthProtein fragment

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionQ13761
    • SpeciesHuman
    • SequenceMGSSHHHHHH SSGLVPRGSH MRSMVDVLAD HAGELVRTDS PNFLCSVLPS HWRCNKTLPV AFKVVALGDV PDGTVVTVMA GNDENYSAEL RNASAVMKNQ VARFNDLRFV GRSGRGKSFT LTITVFTNPT QVATYHRAIK VTVDGPREPR RHRQK
    • Molecular weight17 kDa including tags
    • Amino acids53 to 186
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab95893 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF-TOF
  • Purity> 95 % SDS-PAGE.
    ab95893 is purified using conventional chromatography techniques.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 20% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0

General Info

  • Alternative names
    • Acute myeloid leukemia 2 protein
    • Acute myeloid leukemia gene 2
    • AML 2
    • AML2
    • CBF alpha 3
    • CBF-alpha-3
    • CBFA 3
    • CBFA3
    • core binding factor
    • Core binding factor alpha 3 subunit
    • Core binding factor runt domain alpha subunit 3
    • Core binding factor subunit alpha 3
    • core-binding factor
    • Core-binding factor subunit alpha-3
    • Oncogene AML 2
    • Oncogene AML-2
    • PEA2 alpha C
    • PEA2-alpha C
    • PEBP2 alpha C
    • PEBP2-alpha C
    • Pebp2a3
    • PEBP2aC
    • Polyomavirus enhancer binding protein 2 alpha C subunit
    • Polyomavirus enhancer-binding protein 2 alpha C subunit
    • runt domain alpha subunit 3
    • runt related transcription factor 3
    • Runt-related transcription factor 3
    • RUNX 3
    • Runx3
    • RUNX3_HUMAN
    • SL3 3 enhancer factor 1 alpha C subunit
    • SL3-3 enhancer factor 1 alpha C subunit
    • SL3/AKV core binding factor alpha C subunit
    • SL3/AKV core-binding factor alpha C subunit
    • Transcription factor AML2
    see all
  • FunctionCBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters.
  • Sequence similaritiesContains 1 Runt domain.
  • DomainA proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes.
  • Post-translational
    modifications
    Phosphorylated on tyrosine residues by SRC. Phosphorylated by LCK and FYN.
  • Cellular localizationNucleus. Cytoplasm. The tyrosine phosphorylated form localizes to the cytoplasm.
  • Information by UniProt

Recombinant Human RUNX3 protein images

  • 15% SDS-PAGE showing ab95893 at approximately 17.1kDa (3µg).

References for Recombinant Human RUNX3 protein (ab95893)

ab95893 has not yet been referenced specifically in any publications.

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