FunctionPlays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine.
Tissue specificityExpressed in heart and skeletal muscle.
Sequence similaritiesBelongs to the S-100 family. Contains 2 EF-hand domains.
Cellular localizationCytoplasm. Secreted. Secretion is mediated by exposure to stress and requires copper ions.