Overview

  • Product nameRecombinant Human S100A12 protein
  • Protein lengthFull length protein

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionP80511
    • SpeciesHuman
    • SequenceMKHHHHHHAS TKLEEHLEGI VNIFHQYSVR KGHFDTLSKG ELKQLLTKEL ANTIKNIKDK AVIDEIFQGL DANQDEQVDF QEFISLVAIA LKAAHYHTHK E
    • Molecular weight12 kDa including tags
    • Amino acids2 to 92
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab103393 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 50mM Sodium chloride, 20mM Tris, pH 7.5

  • ReconstitutionAdd deionized water to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely. Filter the product by an appropriate sterile filter before using it in the cell culture.

General Info

  • Alternative names
    • CAAF1
    • CAGC
    • Calcitermin
    • Calcium-binding protein in amniotic fluid 1
    • Calgranulin C
    • Calgranulin-C
    • Calgranulin-related protein
    • CGRP
    • EN RAGE
    • EN-RAGE
    • ENRAGE
    • Extracellular newly identified RAGE-binding protein
    • migration inhibitory factor-related protein 6
    • MRP6
    • Neutrophil S100 protein
    • p6
    • Protein S100 A12
    • S100 calcium binding protein A12
    • S100 calcium-binding protein A12
    • S100 calcium-binding protein A12 (calgranulin C)
    • S100A12
    • S10AC_HUMAN
    see all
  • FunctionCalcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus. Binds calcium, zinc and copper. Presence of zinc increases the affinity for calcium. Plays an important role in the inflammatory response. Interaction with AGER on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators.
  • Tissue specificityMonocytes and lymphocytes.
  • Sequence similaritiesBelongs to the S-101 family.
    Contains 2 EF-hand domains.
  • Information by UniProt

Recombinant Human S100A12 protein images

  • 14% SDS-PAGE analysis of 5 µg ab103393
    Lane 1: reduced and heated sample
    Lane 2: non reduced and non heated sample

References for Recombinant Human S100A12 protein (ab103393)

This product has been referenced in:
  • Lorenzi R  et al. Soluble form of receptor for advanced glycation end-products (sRAGE): do sRAGE ligands or anti-sRAGE auto-antibodies interfere with sRAGE quantification? Ann Clin Biochem N/A:N/A (2013). Read more (PubMed: 23982266) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"