This product is an active protein and may elicit a biological response in vivo, handle with caution.
Extracellular signal-regulated kinase 6
MAP kinase 12
MAP kinase p38 gamma
Mitogen Activated Protein Kinase 12
Mitogen activated protein kinase 3
Mitogen activated protein kinase p38 gamma
Mitogen-activated protein kinase 12
Mitogen-activated protein kinase p38 gamma
Stress Activated Protein Kinase 3
Stress-activated protein kinase 3
FunctionResponds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation.
Tissue specificityHighly expressed in skeletal muscle and heart.
Sequence similaritiesBelongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Contains 1 protein kinase domain.
DomainThe TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
Post-translational modificationsDually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.
Cellular localizationCytoplasm. Mitochondrion. Mitochondrial when associated with SH3BP5.