Overview

Description

  • NatureRecombinant
  • SourceBaculovirus infected Sf9 cells
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab45160 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Purity> 90 % SDS-PAGE.

  • FormLiquid
  • Additional notesRecombinant full-length human SAPK3 was expressed by baculovirus in Sf9 insect cells.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

General Info

  • Alternative names
    • ERK 3
    • ERK 5
    • ERK 6
    • ERK-6
    • ERK3
    • ERK6
    • Extracellular signal-regulated kinase 6
    • MAP kinase 12
    • MAP kinase p38 gamma
    • MAPK 12
    • Mapk12
    • Mitogen Activated Protein Kinase 12
    • Mitogen activated protein kinase 3
    • Mitogen activated protein kinase p38 gamma
    • Mitogen-activated protein kinase 12
    • Mitogen-activated protein kinase p38 gamma
    • MK12_HUMAN
    • P38 GAMMA
    • P38GAMMA
    • PRKM12
    • SAPK 3
    • SAPK-3
    • SAPK3
    • Stress Activated Protein Kinase 3
    • Stress-activated protein kinase 3
    see all
  • FunctionResponds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation.
  • Tissue specificityHighly expressed in skeletal muscle and heart.
  • Sequence similaritiesBelongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
    Contains 1 protein kinase domain.
  • DomainThe TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Post-translational
    modifications
    Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.
  • Cellular localizationCytoplasm. Mitochondrion. Mitochondrial when associated with SH3BP5.
  • Information by UniProt

Recombinant Human SAPK3 protein images

References for Recombinant Human SAPK3 protein (ab45160)

ab45160 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab45160.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"