This product is an active protein and may elicit a biological response in vivo, handle with caution.
MAP kinase 13
MAP kinase p38 delta
Mitogen activated protein kinase 13
Mitogen-activated protein kinase 13
Mitogen-activated protein kinase p38 delta
Stress activated protein kinase 4
Stress-activated protein kinase 4
FunctionResponds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K.
Tissue specificityExpressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells.
Sequence similaritiesBelongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Contains 1 protein kinase domain.
DomainThe TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
Post-translational modificationsDually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme.