Recombinant human SCGF beta protein (ab9836)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human
    • Molecular weight
      36 kDa

Associated products

Specifications

Our Abpromise guarantee covers the use of ab9836 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    SDS-PAGE

  • Endotoxin level
    < 0.100 Eu/µg
  • Form
    Lyophilised
  • Additional notes
    The ED50, determined by its inhibitory effect on the proliferation of TF-1 cells previously grown in media containing GM-CSF, is <7.0ng/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7
    Constituents: 0.16% Sodium phosphate, 0.18% Sodium chloride, 0.015% DTT

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • C type lectin domain family 11 member A
    • C type lectin superfamily member 3
    • C-type lectin domain family 11 member A
    • C-type lectin superfamily member 3
    • CLC11_HUMAN
    • CLEC11A
    • CLECSF3
    • LSLCL
    • Lymphocyte secreted C type lectin
    • Lymphocyte secreted C-type lectin
    • p47
    • Stem cell growth factor
    see all
  • Function
    Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines, including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation.
  • Tissue specificity
    Expressed in skeletal tissues including bone marrow, chondrocytes, primary ossification center-associated cells, the perichondrium and periosteum. Lower levels of expression were detected in spleen, thymus, appendix and fetal liver.
  • Sequence similarities
    Contains 1 C-type lectin domain.
  • Developmental stage
    In the bone marrow, expression is limited to immature neutrophils. Expression was not detected in circulating mature neutrophils.
  • Post-translational
    modifications
    O-glycosylated. Probably sulfated on the O-glycans.
  • Cellular localization
    Cytoplasm. Secreted.
  • Information by UniProt

References

ab9836 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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