The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Peripheral nerve sodium channel 5
Sensory neuron sodium channel 2
Sodium channel protein type 11 subunit alpha
Sodium channel protein type XI subunit alpha
Sodium channel voltage gated type XI alpha
Sodium channel voltage gated type XI alpha polypeptide
Sodium channel voltage gated type XI alpha subunit
Sodium channel voltage gated type XII alpha polypeptide
Voltage gated sodium channel Nav1.9
Voltage gated sodium channel subunit alpha Nav1.9
Voltage-gated sodium channel subunit alpha Nav1.9
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization.
Expressed in the dorsal root ganglia and trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta.
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.9/SCN11A subfamily.
The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
Phosphorylation at Ser-1341 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.